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#What is the NMN, which has also attracted the attention of famous Japanese entrepreneur Mr.Horiemon?


NMN (nicotinamide mononucleotide) is a supplement that has attracted a lot of attention in the health and anti-ageing field in recent years. Many people have become interested in its benefits, especially since Japanese entrepreneur Takafumi Horie (Holliemon) talked about it. In this article, we will objectively examine the pros and cons of NMN, its efficacy and explore whether it is actually effective.


 Subtitle: comprehensive validation of NMN (nicotinamide mononucleotide).


1.  What is NMN?

NMN is a derivative of vitamin B3 (niacin), which is converted in the body to NAD+ (nicotinamide adenine dinucleotide) NAD+ is an essential molecule in the regulation of energy metabolism, DNA repair and gene expression, which underlies the health benefits of NMN.

2.  relationship with mitochondria

Mitochondria are the energy-producing factories of the cell and NAD+ is essential for their energy production processes; NMN intake is expected to increase NAD+ levels in the body and improve mitochondrial function. This is believed to contribute to improved energy metabolism and the prevention of ageing.

3. Benefits of NMN 

Anti-ageing effects.

Animal studies have shown that NMN prolongs life and improves health span. In a study in mice, NMN supplementation delayed the onset of age-related diseases and improved health.

Metabolic improvements.

NMN has been reported to improve insulin sensitivity and help manage blood glucose levels. In particular, NMN has been shown to improve insulin sensitivity in women with pre-diabetic conditions (SpringerLink).

Improved cognitive function.

NAD+ is also involved in the function of nerve cells in the brain, and NMN intake may improve cognitive function. This is expected to have a preventive effect against neurodegenerative diseases such as Alzheimer's disease.

*TND11238, a recent hot topic?

TND1128 and NMN Hydrogen

TND1128 is a product that combines hydrogen and NMN, with the active oxygen scavenging capacity of hydrogen complementing the effects of NMN; to maximise the benefits of NMN, it makes sense to use it in combination with hydrogen, which has antioxidant properties (NMN Research Institute of Tokyo Pharmaceutical Co. ) (E-Expo).


4. Effectiveness of commercially available NMN. 

Commercial NMN supplements are expensive, but scientific evidence on their effectiveness is still limited. Small clinical trials have shown that NMN may contribute to health, but large-scale, long-term studies are needed. For example, clinical trials in healthy middle-aged adults have confirmed that NMN supplementation contributes to improved muscle strength and fitness, but not all health indicators were improved​ (SpringerLink)​。

5. Disadvantages of the NMN  

Lack of scientific evidence

While many promising results on the effects of NMN have been obtained in animal studies, research on humans is still in its early stages. As such, there is a lack of sufficient evidence for its long-term safety and efficacy (Nature).

High costs. 

Commercially available NMN supplements are expensive, placing a significant financial burden on the body to take them on an ongoing basis. This is one factor hindering the widespread use of NMN (Aging and Disease).

Supplement quality.

The quality of NMN supplements on the market is variable. Some products do not contain the amount of NMN that is indicated, so you need to choose a reliable product (Aging and Disease). As you can see from your search, there are quite a lot of NMN on the market.

6. how to choose an NMN  

Checking for quality

It is important to choose a reliable brand. Choose products with third-party test results and transparency in the production process.

Purity of ingredients.

Choose products with high NMN purity. It is recommended to check the list of ingredients on the product label and choose a product with low levels of impurities.


NMN is an expensive supplement, but it is important to consider the balance between price and quality. Cost-effectiveness is also an important factor when considering long-term intake.

7. Conclusion

NMN is a dietary supplement that promotes NAD+ production and is expected to have a variety of health benefits, including energy metabolism and anti-ageing effects. However, there is still insufficient scientific evidence for its effects and further research is needed, particularly on its long-term effects on humans.

Also, as an expensive product, it is important to consider quality and cost-effectiveness before making a choice; when considering taking NMN, it is advisable to base your decision on reliable information and consult with a doctor or specialist.

As evidenced by the attention paid to NMN by many celebrities, including Takafumi Horie, expectations for its benefits are high. Ultimately, however, an evaluation based on scientific evidence is necessary and it is important to focus on the results of future research.


References. Fang EF, Kassahun H, Croteau DL, Scheibye-Knudsen M, Marosi K, et al. "NAD+ replenishment improves lifespan and healthspan in ataxia telangiectasia models via mitophagy and DNA repair." Cell Metabolism, 2016. DOI: 10.1016/j.cmet.2016.09.004.



Yoshino M, Yoshino J, Kayser BD, Patti GJ, et al. "Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women." Science, 2021. DOI: 10.1126/science.abe9985.



GeroScience. "The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial." 2023. DOI: 10.1007/s11357-023-00720-8.

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